反应详情

Methyl 3-methoxy-5-methylsulfonylbenzoate (D14) (2.94 g) was dissolved in dioxan (18 ml) and lithium hydroxide monohydrate (0.762 g) in water (18 ml) was added. The mixture was stirred at room temperature for 2 h and then sufficient Amberlyst-15 H+ resin was added to adjust the pH to ˜4. The resin was removed by filtration and washed well with dioxan and the combined filtrates were evaporated. The residue was triturated with ether to give D15 as a pale buff solid (2 crops, 2.29 g).

1. additionsufficient Amberlyst-15 H+ resin was added
2. customThe resin was removed by filtration
3. washwashed well with dioxan
4. customthe combined filtrates were evaporated
5. customThe residue was triturated with ether
6. customto give D15 as a pale buff solid (2 crops, 2.29 g)