反应详情

Methyl 3-methylsulfonyl-5-(2-oxopyrrolidin-1-yl)-benzoate (D18) (0.717 g) was suspended in dioxan (3.6 ml) and treated with a solution of lithium hydroxide monohydrate (0.153 g) in water (3.6 ml). The mixture was stirred for 2 h at room temperature and a clear solution was formed. The pH was adjusted to ˜4 by addition of Amberlyst-15 H+ resin. The resin was removed by filtration and washed well with dioxan. The combined filtrates were evaporated and the residue dried. Trituration with ether gave D19 (0.51 g) as a pale cream solid.

1. customa clear solution was formed
2. additionThe pH was adjusted to ˜4 by addition of Amberlyst-15 H+ resin
3. customThe resin was removed by filtration
4. washwashed well with dioxan
5. customThe combined filtrates were evaporated
6. customthe residue dried
7. customTrituration with ether gave D19 (0.51 g) as a pale cream solid