4-[N-Acetyl-N-(2-trifluoroacetylamino-ethyl)-amino]-nitrobenzene → 4-[N-acetyl-N-(2-trifluoroacetylamino-ethyl)-amino]-aniline

HRID 1373116Notes

Reaction equation

HRID 1373116 reaction equation
[C:1]([N:4]([C:14]1[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][CH:15]=1)[CH2:5][CH2:6][NH:7][C:8](=[O:13])[C:9]([F:12])([F:11])[F:10])(=[O:3])[CH3:2].[H][H]>CO.[Pd]>[C:1]([N:4]([C:14]1[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=1)[CH2:5][CH2:6][NH:7][C:8](=[O:13])[C:9]([F:11])([F:12])[F:10])(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 180057974-[N-Acetyl-N-(2-trifluoroacetylamino-ethyl)-amino]-nitrobenzeneHCID 178418361HCID 178418361, compound

Product 1

HCID 120470014-[N-acetyl-N-(2-trifluoroacetylamino-ethyl)-amino]-aniline

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

0.7 g (2.1 mmol) of 4-[N-acetyl-N-(2-trifluoroacetylamino-ethyl)-amino]-nitrobenzene are dissolved in 20 ml of methanol and after the addition of 100 mg of 10% palladium on activated charcoal hydrogenated with hydrogen for 3 hours. Then the catalyst is filtered off and evaporated down.

Workup

  1. filtrationThen the catalyst is filtered off
  2. customevaporated down

Sources & evidence

ORD record
ord-c364b1ab2c374c409ed4be9aaca699e3
Source dataset
uspto-grants-2007_01
Patent number
US07160901B2

Reaction notes

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