HCID 18005810, compound → HCID 18005730, compound

HRID 1373117Notes

Reaction equation

HRID 1373117 reaction equation
[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][N:14]([C:18]1[CH:23]=[CH:22][C:21]([N+:24]([O-])=O)=[CH:20][CH:19]=1)[C:15](=[O:17])[CH3:16])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>CO.[Pd].CC([O-])=O.CC([O-])=O.[Pb+2]>[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][N:14]([C:18]1[CH:19]=[CH:20][C:21]([NH2:24])=[CH:22][CH:23]=1)[C:15](=[O:17])[CH3:16])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 18005810HCID 18005810, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18005730HCID 18005730, compound

Reagents, catalysts & solvents 2

HCID 131709914Lindlars catalystCatalystHCID 887MethanolSolvent

Procedure

450 mg (1.26 mmol) of 4-[N-(2-benzyloxycarbonylamino-ethyl)-N-acetyl-amino)-nitrobenzene (prepared analogously to Example I) are dissolved in 20 ml of methanol and after the addition of 100 mg of Lindlar catalyst hydrogenated for 2 hours with hydrogen. The catalyst is filtered off, the solution is evaporated down.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe solution is evaporated down

Sources & evidence

ORD record
ord-ba7e5cb951964af38dd0760d19363fc8
Source dataset
uspto-grants-2007_01
Patent number
US07160901B2

Reaction notes

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