反应详情

2.3 g (8.4 mmol) of 4-(N-aminocarbonylmethyl-N-methylsulphonyl-amino)-nitrobenzene are refluxed in 35 ml (35 mmol) of borane-THF (1 M solution in THF) 7 hours. Then 30 ml of 6 N hydrochloric acid are added, and the mixture is refluxed for another 8 hours. The solvent is distilled off, the residue is mixed with water and extracted with ethyl acetate. The aqueous phase is made alkaline with potassium carbonate and extracted with dichloromethane. The organic phase is separated off, dried and evaporated down.

1. temperaturethe mixture is refluxed for another 8 hours
2. distillationThe solvent is distilled off
3. additionthe residue is mixed with water
4. extractionextracted with ethyl acetate
5. extractionextracted with dichloromethane
6. customThe organic phase is separated off
7. customdried
8. customevaporated down