1-Boc-4-(4-Nitrobenzyl)piperazine → tert-Butyl 4-((4-aminophenyl)methyl)piperazine-1-carboxylate

HRID 1373127Notes

Reaction equation

HRID 1373127 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>[Ni].C(OCC)(=O)C.CO>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 235069461-Boc-4-(4-Nitrobenzyl)piperazine

Product 1

HCID 12045001tert-Butyl 4-((4-aminophenyl)methyl)piperazine-1-carboxylate

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 21584119Ethylacetate methanolSolvent

Procedure

Prepared analogously to Example Id by catalytic hydrogenation of 4-(4-tert.butoxycarbonyl-piperazinomethyl)-nitrobenzene with Raney nickel in ethyl acetate/methanol (1:1).

Sources & evidence

ORD record
ord-759e663d1711498ebf5b1a3cf04e6d04
Source dataset
uspto-grants-2007_01
Patent number
US07160901B2

Reaction notes

Loading…