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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1373127Generated: November 1, 2026

1-Boc-4-(4-Nitrobenzyl)piperazine → tert-Butyl 4-((4-aminophenyl)methyl)piperazine-1-carboxylate

https://huagongshe.com/reaction/1373127

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Boc-4-(4-Nitrobenzyl)piperazineHCID 23506946—
CatalystNickelHCID 935—
SolventEthylacetate methanolHCID 21584119—
Producttert-Butyl 4-((4-aminophenyl)methyl)piperazine-1-carboxylateHCID 12045001—

Reaction Steps

Prepared analogously to Example Id by catalytic hydrogenation of 4-(4-tert.butoxycarbonyl-piperazinomethyl)-nitrobenzene with Raney nickel in ethyl acetate/methanol (1:1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07160901B2
Source datasetuspto-grants-2007_01
ORD IDord-759e663d1711498ebf5b1a3cf04e6d04
Source noteuspto-grants-2007_01