Water → 1-Acetyl-5-phenylsulphonylamino-2-indolinone

HRID 1373135Notes

Reaction equation

HRID 1373135 reaction equation
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([NH2:13])=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:14])(=[O:3])[CH3:2].[C:15]1([S:21](Cl)(=[O:23])=[O:22])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.O>N1C=CC=CC=1>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([NH:13][S:21]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)(=[O:23])=[O:22])=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:14])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 7369Benzenesulfonyl chlorideHCID 120469981-Acetyl-5-aminoindolin-2-one

Product 1

HCID 120469991-Acetyl-5-phenylsulphonylamino-2-indolinone

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

20.0 g (105 mmol) of 1-acetyl-5-amino-2-indolinone are placed in 200 ml of pyridine, combined with 15.3 ml (120 mmol) of benzenesulphonic acid chloride while cooling with ice and stirred for 2 hours. Then the mixture is poured onto 1.8 l of water and suction filtered. The crude product is stirred into acetone, suction filtered and dried.

Workup

  1. temperaturewhile cooling with ice
  2. filtrationfiltered
  3. stirringThe crude product is stirred into acetone, suction
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-a612f5a21f0549be8ec6f84d7637056d
Source dataset
uspto-grants-2007_01
Patent number
US07160901B2

Reaction notes

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