HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-Acetyl-5-phenylsulphonylamino-2-indolinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Benzenesulfonyl chloride | HCID 7369 | — |
| Reactant | 1-Acetyl-5-aminoindolin-2-one | HCID 12046998 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 1-Acetyl-5-phenylsulphonylamino-2-indolinone | HCID 12046999 | — |
Reaction Steps
20.0 g (105 mmol) of 1-acetyl-5-amino-2-indolinone are placed in 200 ml of pyridine, combined with 15.3 ml (120 mmol) of benzenesulphonic acid chloride while cooling with ice and stirred for 2 hours. Then the mixture is poured onto 1.8 l of water and suction filtered. The crude product is stirred into acetone, suction filtered and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07160901B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-a612f5a21f0549be8ec6f84d7637056d |
| Source note | uspto-grants-2007_01 |