Ammonia → HCID 68807071, compound

HRID 1373199Notes

Reaction equation

HRID 1373199 reaction equation
FC1C(O[C:9]([C:11]2([F:30])[C:20]([NH:21][C:22]3[CH:27]=[CH:26][C:25]([I:28])=[CH:24][C:23]=3[F:29])=[CH:19][C:14]3=[N:15][CH2:16][N:17]([CH3:18])[C:13]3=[CH:12]2)=[O:10])=C(F)C(F)=C(F)C=1F.[NH3:35]>CN(C=O)C>[F:30][C:11]1([C:9]([NH2:35])=[O:10])[C:20]([NH:21][C:22]2[CH:27]=[CH:26][C:25]([I:28])=[CH:24][C:23]=2[F:29])=[CH:19][C:14]2=[N:15][CH2:16][N:17]([CH3:18])[C:13]2=[CH:12]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86596373HCID 86596373, compound2×

Product 1

HCID 68807071HCID 68807071, compoundYield 93.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A reaction vial was charged with the product of Example 1, Step J, 5-fluoro-6-(2-fluoro-4-iodo-phenylamino)-3-methyl-3H-benzoimidazole-5-carboxylic acid pentafluorophenyl ester (0.5229 g, 0.8585 mmol) and DMF (1 mL). Saturated aqueous ammonia (3 mL) was added to the solution, giving a white precipitate immediately. The mixture was stirred for 10 minutes and then was vacuum-filtered and suctioned to afford the white solid product (0.3509 g). Yield: 93.3%, mp 265–268° C. DEC.

Workup

  1. customA reaction
  2. customgiving a white precipitate immediately
  3. filtrationwas vacuum-filtered

Sources & evidence

ORD record
ord-85d057932680454ab3a8210f2927e398
Source dataset
uspto-grants-2007_01
Patent number
US07160915B2

Reaction notes

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