HCID 21073115, compound → HCID 21073113, compound

HRID 1373234Notes

Reaction equation

HRID 1373234 reaction equation
[C:1]([O:5][C:6](=[O:25])[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[N+:22]([O-])=O)=[CH:11][CH:10]=1)([CH3:4])([CH3:3])[CH3:2]>[C].[Pd].C(O)C>[C:1]([O:5][C:6](=[O:25])[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[NH2:22])=[CH:11][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 21073115HCID 21073115, compound

Product 1

HCID 21073113HCID 21073113, compoundYield 86.9%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

10% carbon-palladium (0.2 g) was added to an ethanol (20 ml) solution of tert-butyl[4-(2-nitrophenoxy)benzyl]carbamate (1.43 g, 4.15 mmols). The resulting mixture was hydrogenated at room temperature under atmospheric pressure. The catalyst was removed through filtration, and the filtrate was concentrated under reduced pressure. An oil of tert-butyl[4-(2-aminophenoxy)benzyl]carbamate (1.13 g, 86.9%) was obtained.

Workup

  1. customwas hydrogenated at room temperature under atmospheric pressure
  2. customThe catalyst was removed through filtration
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d8efe5cfdcfb40b197d15abced97702a
Source dataset
uspto-grants-2007_01
Patent number
US07160887B1

Reaction notes

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