反应详情

5% carbon-palladium (1.3 g) was added to an ethyl acetate (100 ml) solution of tert-butyl 4-[4-(5-chloro-2-nitrophenoxy)phenyl]piperazine-1-carboxylate (5.64 g, 13 mmols). The resulting mixture was hydrogenated at room temperature under atmospheric pressure. The catalyst was removed through filtration, and the filtrate was concentrated under reduced pressure. The residue was purified through silica gel column chromatography to give a crystal of tert-butyl 4-[4-(2-amino-5-chlorophenoxy)phenyl]piperazine-1-carboxylate (4.0 g, 76%).

1. customwas hydrogenated at room temperature under atmospheric pressure
2. customThe catalyst was removed through filtration
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe residue was purified through silica gel column chromatography