2-Bromoethanol → HCID 59971154, compound

HRID 1373293Notes

Reaction equation

[CH3:1][O:2][CH2:3][C@@H:4]1[CH2:8][CH2:7][CH2:6][NH:5]1.Br[CH2:10][CH2:11][OH:12]>>[OH:12][CH2:11][CH2:10][N:5]1[CH2:6][CH2:7][CH2:8][C@H:4]1[CH2:3][O:2][CH3:1]

Participants

Reactant 2

HCID 108982-Bromoethanol

HCID 671217(S)-(+)-2-(Methoxymethyl)pyrrolidine

Product 1

HCID 59971154HCID 59971154, compound

Procedure

Using an analogous procedure to those described in Note [39] immediately above, (2S)-2-methoxymethylpyrrolidine was reacted with 2-bromoethanol to give (2S)-1-(2-hydroxyethyl)-2-methoxymethylpyrrolidine; NMR Spectrum: (CDCl3) 1.5–1.65 (m, 1H), 1.65–1.8 (m, 2H), 1.8–2.0 (m, 2H), 2.3 (m, 1H), 2.6 (m, 1H), 2.8 (m, 1H), 2.95–3.05 (m, 1H), 3.17 (m, 1H), 3.3 (t, 1H), 3.35 (t, 1H), 3.37 (s, 3H), 3.5–3.7 (m, 2H).

Sources & evidence

ORD record: ord-3ec3d17da3b744e9b4c5ec6624230620
Source dataset: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07160891B2

Reaction notes

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