Hydrochloric Acid → HCID 18551811, compound

HRID 1373419Notes

Reaction equation

HRID 1373419 reaction equation
Cl.[CH2:2]([S:9][C:10]1[S:11][CH:12](O)[C:13](C)(O)[N:14]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:18]([OH:20])C>>[CH2:2]([S:9][C:10]1[S:11][C:12]([CH2:18][OH:20])=[CH:13][N:14]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 68505920HCID 68505920, compound

Product 1

HCID 18551811HCID 18551811, compound

Conditions

Temperature
50 °C

Procedure

0.2 ml of concentrated hydrochloric acid is added to 3.0 g of 2-benzylsulfanyl-5-hydroxy-methyl-4,5-dihydrothiazol-4-ol in 25 ml of ethanol. The mixture is stirred at 50° C. for 12 hours, the solvent is removed in vacuo, and the residue is chromatographed on silica gel (etherhexane; 1:1). The title compound is obtained in the form of a yellow oil (compound 3.1).

Workup

  1. customthe solvent is removed in vacuo
  2. customthe residue is chromatographed on silica gel (etherhexane; 1:1)

Sources & evidence

ORD record
ord-4ee79655f3b14badb2b31f4924551cd5
Source dataset
uspto-grants-2007_01
Patent number
US07161011B2

Reaction notes

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