HCID 18551810, compound → HCID 18551811, compound

HRID 1373420Notes

Reaction equation

HRID 1373420 reaction equation
[CH2:1]([S:8][C:9]1[S:10][C:11]([CH:14]=[O:15])=[CH:12][N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(OCC)(=O)C.[Pt]=O>[CH2:1]([S:8][C:9]1[S:10][C:11]([CH2:14][OH:15])=[CH:12][N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 18551810HCID 18551810, compound

Product 1

HCID 18551811HCID 18551811, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 8857Ethyl AcetateSolvent

Procedure

325 mg of 2-benzylsulfanyl-thiazole-5-carbaldehyde in 35 ml of ethyl acetate are hydrogenated with 14 mg of FeCl2×4H2O and 175 mg of platinum oxide under normal pressure for 64 hours at room temperature under a hydrogen atmosphere. The reaction mixture is filtered off and extracted with water. The organic phase is dried over sodium sulfate and concentrated in vacua. The title compound is obtained in the form of an oil (compound 3.1).

Workup

  1. filtrationThe reaction mixture is filtered off
  2. extractionextracted with water
  3. dry with materialThe organic phase is dried over sodium sulfate
  4. concentrationconcentrated in vacua

Sources & evidence

ORD record
ord-aac91174f5cf410f8b1200d5225165cf
Source dataset
uspto-grants-2007_01
Patent number
US07161011B2

Reaction notes

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