Hydrochloric Acid → 4,6-Dimethylpyrimidine-5-carboxylic acid

HRID 1373460Notes

Reaction equation

HRID 1373460 reaction equation
[CH3:1][C:2]1[C:7]([C:8]([O:10]C)=[O:9])=[C:6]([CH3:12])[N:5]=[CH:4][N:3]=1.[OH-].[Na+].Cl>O>[CH3:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[C:6]([CH3:12])[N:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 29949935Methyl 4,6-dimethylpyrimidine-5-carboxylate

Product 1

HCID 149222224,6-Dimethylpyrimidine-5-carboxylic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

The crude methyl 4,6-dimethylpyrimidine-5-carboxylate from the previous example to 20° C. was cooled and water (86 ml) was charged. 25% sodium hydroxide solution (75.5 ml) was charged and the batch was warmed to 50° C. for 90 minutes. The batch was cooled to between −5 and 0° C. and concentrated hydrochloric acid was charged slowly keeping the temperature within the range of −5 to +5° C. until a pH of 1.5 was reached. The batch was agitated for at least one hour at 0° C. The batch was filtered and the product washed with ice cold water (2×43 ml). The batch was dried under vacuum at 40–45° C. Yield of 4,6-dimethylpyrimidine-5-carboxylic acid was 59 g. m. p. 203–204° C., 1H NMR (D2O): δ2.57 (6H, s, CH3), δ9.00 (1H, s, ArH). 13H CMR (D2O): δ170.00, δ164.39, δ151.29, δ133.47, δ20.85. HR-MS; Calculated for C7H9N2O2, m/z=153.0664. Found 153.0667.

Workup

  1. customto 20° C.
  2. temperatureThe batch was cooled to between −5 and 0° C.
  3. customwithin the range of −5 to +5° C.
  4. filtrationThe batch was filtered
  5. washthe product washed with ice cold water (2×43 ml)
  6. customThe batch was dried under vacuum at 40–45° C

Sources & evidence

ORD record
ord-253187b9e0424bfdb994054bfb4c9211
Source dataset
uspto-grants-2007_01
Patent number
US07161024B2

Reaction notes

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