Methanol → 4'-[2-({8-[2-(Acetylamino)ethyl]-2-naphthyl}oxy)ethoxy]-[1,1'-biphenyl]-4-carboxylic acid

HRID 1373481노트

반응식

HRID 1373481 반응식
[C:1]([NH:4][CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:16]=1[CH:15]=[C:14]([O:17][CH2:18][CH2:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][C:30]([C:33]([O:35]C)=[O:34])=[CH:29][CH:28]=3)=[CH:23][CH:22]=1)[CH:13]=[CH:12]2)(=[O:3])[CH3:2].CO.O.[OH-].[Na+]>C1COCC1>[C:1]([NH:4][CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:16]=1[CH:15]=[C:14]([O:17][CH2:18][CH2:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][C:30]([C:33]([OH:35])=[O:34])=[CH:29][CH:28]=3)=[CH:23][CH:22]=1)[CH:13]=[CH:12]2)(=[O:3])[CH3:2]

참가 물질

6

반응물 4

HCID 887MethanolHCID 962WaterHCID 14798Sodium HydroxideHCID 15540840Methyl 4'-[2-({8-[2-(acetylamino)ethyl]-2-naphthyl}oxy)ethoxy]-[1,1'-biphenyl]-4-carboxylate

생성물 1

HCID 155408414'-[2-({8-[2-(Acetylamino)ethyl]-2-naphthyl}oxy)ethoxy]-[1,1'-biphenyl]-4-carboxylic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

In a 100 ml round-bottomed flask, 19 mmol of the compound obtained in Example 1 are suspended in 25 ml of THF, and then 15 ml of methanol, 15 ml of water and 38 mmol of sodium hydroxide are added. The reaction mixture is maintained at ambient temperature with stirring for 10 hours. The solution is subsequently concentrated, poured into water and then acidified with 12M HCl. The precipitate obtained is filtered off, washed with water and recrystallised to yield the title product.

후처리

  1. concentrationThe solution is subsequently concentrated
  2. additionpoured into water
  3. customThe precipitate obtained
  4. filtrationis filtered off
  5. washwashed with water
  6. customrecrystallised

출처 및 근거

ORD 기록
ord-b2091e56b218413f97fcb4194ca9bd8b
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07161035B2

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