Potassium Carbonate → HCID 23077362, compound

HRID 1373504Notes

Reaction equation

HRID 1373504 reaction equation
C(=O)([O-])[O-].[K+].[K+].[CH2:7]([O:14][C:15]([NH:17][CH:18]([CH3:23])[CH2:19][S:20]([OH:22])=[O:21])=[O:16])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[Br:24]Br>O>[CH2:7]([O:14][C:15]([NH:17][CH:18]([CH3:23])[CH2:19][S:20]([Br:24])(=[O:22])=[O:21])=[O:16])[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 24408BromineHCID 23077370HCID 23077370, compound

Product 1

HCID 23077362HCID 23077362, compoundYield 102.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

In water (10 ml) was dissolved 0.52 g (3.8 mmol) of potassium carbonate and 1.73 g (6.7 mmol) of 2-(benzyloxycarbonylamino)propane-1-sulfinic acid was added thereto, after which 1.07 g (6.7 mmol) of bromine was added dropwise thereto (water was properly added because crystals were precipitated during the dropwise addition to make stirring difficult). After stirring at room temperature for 30 minutes, the crystals were filtered and then washed with water to obtain 2.30 g (quantitative) of 2-(benzyloxycarbonylamino)propane-1-sulfonyl bromide.

Workup

  1. additionwas added
  2. customwere precipitated during the dropwise addition
  3. stirringAfter stirring at room temperature for 30 minutes
  4. filtrationthe crystals were filtered
  5. washwashed with water

Sources & evidence

ORD record
ord-ab9f474e2db64a558cf47852a8a71ce6
Source dataset
uspto-grants-2007_01
Patent number
US07161032B2

Reaction notes

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