2-Hexyloxirane → 2-Octanol

Temperature

25 °C

To a 50-ml reaction vessel were added 1,2-epoxyoctane (2.56 g, 20.0 mmol), methanol (18 mL), 10% palladium/carbon containing 50% water (425 mg, Pd: 0.20 mmol) and catalytic amount of an amine subsequently, and then the mixture was vigorously stirred under an atmosphere of hydrogen at 25° C. Twenty to forty hours later, 10% palladium/carbon was removed by filtration and methanol was removed by distillation. The selectivity of thus obtained colorless oil was checked by gas chromatographic analysis. The results obtained by adding a various amines and other additives were respectively shown as follows:

1. customTo a 50-ml reaction vessel
2. customTwenty to forty hours later, 10% palladium/carbon was removed by filtration and methanol
3. customwas removed by distillation
4. customThe results obtained

ORD record

ord-2fb42f0fc9a647488b91566ecccb44be

Source dataset

uspto-grants-2007_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07161047B2