1-(2-Chloro-3-piperazin-1-yl-phenyl)-ethanone trifluoroacetate → 7-{4-[4-(3-Acetyl-2-chloro-phenyl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-[1,8]naphthyridin-2-one
반응식
FC(F)(F)C(O)=O.[Cl:8][C:9]1[C:14]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)=[CH:13][CH:12]=[CH:11][C:10]=1[C:21](=[O:23])[CH3:22].[O:24]=[C:25]1[NH:34][C:33]2[N:32]=[C:31]([O:35][CH2:36][CH2:37][CH2:38][CH:39]=O)[CH:30]=[CH:29][C:28]=2[CH2:27][CH2:26]1>>[C:21]([C:10]1[C:9]([Cl:8])=[C:14]([N:15]2[CH2:20][CH2:19][N:18]([CH2:39][CH2:38][CH2:37][CH2:36][O:35][C:31]3[N:32]=[C:33]4[C:28]([CH2:27][CH2:26][C:25](=[O:24])[NH:34]4)=[CH:29][CH:30]=3)[CH2:17][CH2:16]2)[CH:13]=[CH:12][CH:11]=1)(=[O:23])[CH3:22]참가 물질
3
실험 절차
In a manner similar to that of other examples above, 1-(2-chloro-3-piperazin-1-yl-phenyl)-ethanone trifluoroacetate was coupled by reductive amination to 4-(7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde followed by typical workup and purification to give the title compound, mp 138–139° C. MS: APCI: M+1: 457.2 (Exact Mass: 456.19).
후처리
- customfollowed by typical workup and purification
출처 및 근거
- ORD 기록
- ord-e457bcf89d2d4583be40e41242ea03d3
- 출처 데이터셋
- uspto-grants-2007_01
- 특허 번호
- US07160888B2
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