1-(2-Chloro-3-piperazin-1-yl-phenyl)-ethanone trifluoroacetate → 7-{4-[4-(3-Acetyl-2-chloro-phenyl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-[1,8]naphthyridin-2-one

Beteiligte Stoffe

Reaktionsschritte

In a manner similar to that of other examples above, 1-(2-chloro-3-piperazin-1-yl-phenyl)-ethanone trifluoroacetate was coupled by reductive amination to 4-(7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde followed by typical workup and purification to give the title compound, mp 138–139° C. MS: APCI: M+1: 457.2 (Exact Mass: 456.19).

Herkunft & Nachweise