1-(2-Chloro-6-piperazin-1-yl-phenyl)-ethanone → HCID 21073566, Verbindung

HRID 1373556Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1373556
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[C:3]=1[C:14](=[O:16])[CH3:15].[O:17]=[C:18]1[NH:27][C:26]2[N:25]=[C:24]([O:28][CH2:29][CH2:30][CH2:31][CH:32]=O)[CH:23]=[CH:22][C:21]=2[CH:20]=[CH:19]1>>[C:14]([C:3]1[C:2]([Cl:1])=[CH:7][CH:6]=[CH:5][C:4]=1[N:8]1[CH2:13][CH2:12][N:11]([CH2:32][CH2:31][CH2:30][CH2:29][O:28][C:24]2[N:25]=[C:26]3[C:21]([CH:20]=[CH:19][C:18](=[O:17])[NH:27]3)=[CH:22][CH:23]=2)[CH2:10][CH2:9]1)(=[O:16])[CH3:15]

Komponenten

3

Edukt 2

HCID 210731441-(2-Chloro-6-piperazin-1-yl-phenyl)-ethanoneHCID 210733804-(7-Oxo-7,8-dihydro-1,8-naphthyridin-2-yloxy)butanal

Produkt 1

HCID 21073566HCID 21073566, Verbindung

Versuchsvorschrift

In a manner similar to that of other examples above, 1-(2-chloro-6-piperazin-1-yl-phenyl)-ethanone was coupled by reductive amination to 4-(7-oxo-7,8-dihydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde followed by typical workup and purification to give the title compound. MS: APCI: M+1: 455.2 (Exact Mass: 454.18).

Aufarbeitung

  1. customfollowed by typical workup and purification

Quellen und Nachweise

ORD-Eintrag
ord-7475b156f6684abc96ecb1fc988bb3e7
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07160888B2

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