2-(Methylsulfonyl)pyrido[2,3-d]pyrimidin-7(1H)-one → 2-[4-(4-Naphthalen-1-yl-piperazin-1-yl)-butoxy]-8H-pyrido[2,3-d]pyrimidin-7-one

HRID 1373625Notes

Reaction equation

HRID 1373625 reaction equation
CS([C:5]1[N:6]=[CH:7][C:8]2[CH:14]=[CH:13][C:12](=[O:15])[NH:11][C:9]=2[N:10]=1)(=O)=O.[C:16]1([N:26]2[CH2:31][CH2:30][N:29]([CH2:32][CH2:33][CH2:34][CH2:35][OH:36])[CH2:28][CH2:27]2)[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][CH:17]=1>>[C:16]1([N:26]2[CH2:27][CH2:28][N:29]([CH2:32][CH2:33][CH2:34][CH2:35][O:36][C:5]3[N:6]=[CH:7][C:8]4[CH:14]=[CH:13][C:12](=[O:15])[NH:11][C:9]=4[N:10]=3)[CH2:30][CH2:31]2)[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 183749342-(Methylsulfonyl)pyrido[2,3-d]pyrimidin-7(1H)-oneHCID 210733524-(4-Naphthalen-1-yl-piperazin-1-yl)-butan-1-ol

Product 1

HCID 210732402-[4-(4-Naphthalen-1-yl-piperazin-1-yl)-butoxy]-8H-pyrido[2,3-d]pyrimidin-7-one

Procedure

Following the same procedure as in Example H12 and starting from 2-methanesulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one (300 mg, 1.332 mmol, U.S. Pat. No. 6,498,163) and 4-(4-naphthalen-1-yl-piperazin-1-yl)-butan-1-ol (416 mg, 1.465 mmol), the title compound was made as a solid (300 mg, 0.683 mmol, 51.3%). MS: APCI: M+1: 430.2 (Exact Mass: 429.22).

Sources & evidence

ORD record
ord-8b004516384b42ecb7c0482d8e0b0525
Source dataset
uspto-grants-2007_01
Patent number
US07160888B2

Reaction notes

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