2-(Methylsulfonyl)pyrido[2,3-d]pyrimidin-7(1H)-one → 2-[4-(4-Naphthalen-1-yl-piperazin-1-yl)-butoxy]-8H-pyrido[2,3-d]pyrimidin-7-one

Participants

Reaction Steps

Following the same procedure as in Example H12 and starting from 2-methanesulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one (300 mg, 1.332 mmol, U.S. Pat. No. 6,498,163) and 4-(4-naphthalen-1-yl-piperazin-1-yl)-butan-1-ol (416 mg, 1.465 mmol), the title compound was made as a solid (300 mg, 0.683 mmol, 51.3%). MS: APCI: M+1: 430.2 (Exact Mass: 429.22).

Provenance & Evidence