HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-((7-Oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)oxy)butanal → 7-{4-[4-(2-Oxo-1,2,3,4-tetrahydro-quinolin-8-yl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-[1,8]naphthyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-((7-Oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)oxy)butanal | HCID 21073377 | — |
| Reactant | 8-piperazin-1-yl-3,4-dihydro-1H-quinolin-2-one hydrochloride | HCID 21073944 | — |
| Product | 7-{4-[4-(2-Oxo-1,2,3,4-tetrahydro-quinolin-8-yl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-[1,8]naphthyridin-2-one | HCID 21073625 | — |
Reaction Steps
In a manner similar to that of other examples above, 8-piperazin-1-yl-3,4-dihydro-1H-quinolin-2-one hydrochloride (Chem. Pharm. Bull. 1984, 32, 2100–2110) was coupled by reductive amination to 4-(7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde followed by typical workup and purification to give the title compound. MS: APCI: M+1: 450.2 (Exact Mass: 449.24).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07160888B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-d65d4609daf04f6698d73b9172127097 |
| Source note | uspto-grants-2007_01 |