反应详情

To a solution of 2-amino-5-chloro-N-(5-chloropyridin-2-yl)benzamide (2.82 g, 10 mmol) in methylene chloride (100 mL) and pyridine (3 mL) was added 4-fluorobenzoyl chloride (1.42 mL, 12 mmol) dropwise at 0° C. The reaction mixture was warmed to room temperature and stirred overnight. Water (50 mL) was added; and the mixture was stirred for 30 min before the solids were filtered, washed with saturated sodium bicarbonate (30 mL), water (30 mL), and ether (50 mL), and dried under vacuum to provide the product (3.2 g, 79%) pure enough to use in the next step.

1. stirringand the mixture was stirred for 30 min before the solids
2. filtrationwere filtered
3. washwashed with saturated sodium bicarbonate (30 mL), water (30 mL), and ether (50 mL)
4. customdried under vacuum