Water → 5-Chloro-2-(4-fluorobenzoylamino)-N-(5-chloropyridin-2-yl)-benzamide

Participants

Reaction Steps

To a solution of 2-amino-5-chloro-N-(5-chloropyridin-2-yl)benzamide (2.82 g, 10 mmol) in methylene chloride (100 mL) and pyridine (3 mL) was added 4-fluorobenzoyl chloride (1.42 mL, 12 mmol) dropwise at 0° C. The reaction mixture was warmed to room temperature and stirred overnight. Water (50 mL) was added; and the mixture was stirred for 30 min before the solids were filtered, washed with saturated sodium bicarbonate (30 mL), water (30 mL), and ether (50 mL), and dried under vacuum to provide the product (3.2 g, 79%) pure enough to use in the next step.

Provenance & Evidence