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HRID 1373716作成日：2026年10月25日

Formaldehyde → 5-Chloro-2-[1-(1-methyl-hexahydroazepin-4-yl)piperidin-4-ylcarbonylamino]-N-(5-chloropyridin-2-yl)benzamide

https://huagongshe.com/reaction/1373716

反応式

関与物質

役割名称HCID仕込み量
反応物FormaldehydeHCID 712—
反応物Sodium cyanoborohydrideHCID 5003444—
反応物5-chloro-2-[1-(hexahydroazepin-4-yl)piperidin-4-ylcarbonylamino]-N-(5-chloropyridin-2-yl)benzamideHCID 21075319—
生成物5-Chloro-2-[1-(1-methyl-hexahydroazepin-4-yl)piperidin-4-ylcarbonylamino]-N-(5-chloropyridin-2-yl)benzamideHCID 21075317—

反応手順

Alternatively, 5-chloro-2-[1-(1-methyl-hexahydroazepin-4-yl)piperidin-4-ylcarbonylamino]-N-(5-chloropyridin-2-yl)-benzamide is prepared by a NaCNBH3 reductive alkylation of 5-chloro-2-[1-(hexahydroazepin-4-yl)piperidin-4-ylcarbonylamino]-N-(5-chloropyridin-2-yl)benzamide with formaldehyde.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07163938B2
出典データセットuspto-grants-2007_01
ORD IDord-99ddf83aa5a9437a9981b1c4182bcd2c
出典メモuspto-grants-2007_01