Methyl 4-(hydroxymethyl)benzoate → HCID 69318823, compound

HRID 1373741Notes

Reaction equation

HRID 1373741 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C@H:12]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[C:13]([NH2:15])=[O:14])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH3:23][O:24][C:25](=[O:34])[C:26]1[CH:31]=[CH:30][C:29]([CH2:32]O)=[CH:28][CH:27]=1>>[CH3:23][O:24][C:25](=[O:34])[C:26]1[CH:31]=[CH:30][C:29]([CH2:32][N:11]([C@@H:12]([C:13](=[O:14])[NH2:15])[C:16]2[CH:17]=[CH:18][C:19]([F:22])=[CH:20][CH:21]=2)[S:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)(=[O:9])=[O:10])=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 81325Methyl 4-(hydroxymethyl)benzoateHCID 69317190HCID 69317190, compound

Product 1

HCID 69318823HCID 69318823, compound

Procedure

The title compound was prepared employing the procedure in Example 2 using (R)-2-(4-chloro-benzenesulfonylamino)-2-(4-fluoro-phenyl)-acetamide and methyl-4-hydroxymethylbenzoate to afford the desired product. Diagnostic 13CNMR (100 MHz, CDCl3) 49.9, 52.3, 63.4, 116.0, 116.2, 127.9, 129.1, 129.5, 129.6, 132.0, 132.1, 139.8, 142.3. MS 491.2 m/z (M+1).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-ff89882c436043e5b45c8f27d7806f44
Source dataset
uspto-grants-2007_01
Patent number
US07163942B2

Reaction notes

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