反应详情

A solution of N-benzyl-(2-ethoxymethy-1H-imidazo[4,5-c]quinolin-1-yl)amine (1.01 g, 3.04 mmol) in 50 mL of CH2Cl2 was treated with MCPBA (77% max., 1.02 g, 4.56 mmol). After stirring for 3 h, the reaction mixture was quenched with 2% Na2CO3 solution and extracted into CH2Cl2. The organic portion was washed with H2O and brine. The organic portion was dried over Na2SO4, filtered and concentrated to give N-benzyl-(2-ethoxymethy-5-oxido-1H-imidazo[4,5-c]quinolin-1-yl)amine (0.99 g) as a light-yellow solid.

1. customthe reaction mixture was quenched with 2% Na2CO3 solution
2. extractionextracted into CH2Cl2
3. washThe organic portion was washed with H2O and brine
4. dry with materialThe organic portion was dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated