反应详情

温度

100 °C

A solution of 2-propyl-1H-imidazo[4,5-c]quinolin-1-amine (4.64 g, 20.5 mmol) in 60 mL of acetonitrile and 15 mL of glacial acetic acid was treated with 2,2-dimethoxypropane (12.6 mL, 103 mmol) and heated to 100° C. under an atmosphere of nitrogen. After 6 d, the reaction mixture was concentrated under reduced pressure to yield a brown oil. The oil was dissolved in 100 mL of CHCl3 and washed with 10% Na2CO3 (2×25 mL), water (25 mL), brine (25 mL), dried over Na2SO4, filtered and concentrated under reduced pressure to give 4.30 g of N-isopropylidene-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)amine as a brown oil.

1. concentrationthe reaction mixture was concentrated under reduced pressure
2. customto yield a brown oil
3. washwashed with 10% Na2CO3 (2×25 mL), water (25 mL), brine (25 mL)
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure