Ethylene Oxide → HCID 73087119, compound

HRID 1374465Notes

Reaction equation

HRID 1374465 reaction equation
[CH3:1][CH:2]([CH3:30])[CH:3]([NH:15][C:16]([CH:18]1[CH2:22][CH:21]([CH2:23][CH2:24][C:25]([F:29])([F:28])[CH2:26][CH3:27])[CH2:20][NH:19]1)=[O:17])[CH:4]1[CH:9]([OH:10])[CH:8]([OH:11])[CH:7]([OH:12])[CH:6]([S:13][CH3:14])[O:5]1.[CH2:31]1[O:33][CH2:32]1>CO>[CH3:30][CH:2]([CH3:1])[CH:3]([NH:15][C:16]([CH:18]1[CH2:22][CH:21]([CH2:23][CH2:24][C:25]([F:29])([F:28])[CH2:26][CH3:27])[CH2:20][N:19]1[CH2:31][CH2:32][OH:33])=[O:17])[CH:4]1[CH:9]([OH:10])[CH:8]([OH:11])[CH:7]([OH:12])[CH:6]([S:13][CH3:14])[O:5]1

Participants

4

Reactant 2

HCID 6354Ethylene OxideHCID 85154260HCID 85154260, compound

Product 1

HCID 73087119HCID 73087119, compoundYield 42%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
4 °C

Procedure

To a solution of the title compound of Example 39 (17.9 mg, 0.039 mmol) in MeOH (2 mL) at 0° C. was added ethylene oxide (0.4 mL). The reaction mixture was stirred at 4° C. overnight. The reaction mixture was concentrated and purified by chromatography to give the title compound as a white solid (8.2 mg, 42%).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. custompurified by chromatography

Sources & evidence

ORD record
ord-405446beb0664e1386609594c4bd5728
Source dataset
uspto-grants-2007_01
Patent number
US07164011B2

Reaction notes

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