L-Lactic Acid → HCID 69507875, compound

HRID 1374558Notes

Reaction equation

HRID 1374558 reaction equation
Cl.[C:2]([N:5]1[CH2:11][C@H:10]([NH2:12])[C:9](=[O:13])[N:8]([CH3:14])[C:7]2[CH:15]=[CH:16][CH:17]=[CH:18][C:6]1=2)(=[O:4])[CH3:3].[C:19](O)(=[O:23])[C@H:20]([CH3:22])[OH:21]>>[C:2]([N:5]1[CH2:11][C@H:10]([NH:12][C:19](=[O:23])[C@@H:20]([OH:21])[CH3:22])[C:9](=[O:13])[N:8]([CH3:14])[C:7]2[CH:15]=[CH:16][CH:17]=[CH:18][C:6]1=2)(=[O:4])[CH3:3]

Participants

3

Reactant 2

HCID 107689L-Lactic AcidHCID 21076593HCID 21076593, compound

Product 1

HCID 69507875HCID 69507875, compound

Procedure

In an analogous manner to that described in Example 53 c), the condensation of (S)-5-acetyl-3-amino-1-methyl-1,3,4,5-tetrahydro-benzo[b][1,4]diazepin-2-one hydrochloride with L-(+)-lactic acid yielded the title compound as a yellow foam; MS: m/e=306 (M+H)+.

Sources & evidence

ORD record
ord-ffbd8b362dd04d5d9b72798c69807c3c
Source dataset
uspto-grants-2007_01
Patent number
US07166587B2

Reaction notes

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