Succinic anhydride → HCID 18521581, compound

HRID 1374580Notes

Reaction equation

HRID 1374580 reaction equation
[C:1]1(=[O:7])[O:6][C:4](=[O:5])[CH2:3][CH2:2]1.[N:8]1([C:13]([CH2:15][N:16]2[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)=[O:14])[CH2:12][CH2:11][CH2:10][CH2:9]1>O1CCOCC1>[O:5]=[C:4]([N:19]1[CH2:18][CH2:17][N:16]([CH2:15][C:13](=[O:14])[N:8]2[CH2:9][CH2:10][CH2:11][CH2:12]2)[CH2:21][CH2:20]1)[CH2:3][CH2:2][C:1]([OH:6])=[O:7]

Participants

4

Reactant 2

HCID 7922Succinic anhydrideHCID 1006141-((Pyrrolidine-1-carbonyl)methyl)piperazine

Product 1

HCID 18521581HCID 18521581, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

0.72 g of succinic anhydride and then 1.5 cm3 of 95% 1-(pyrrolidinocarbonylmethyl)-piperazine are added to 20 cm3 of dioxane in a round-bottomed flask kept under a nitrogen atmosphere. After stirring for 4.75 hours at room temperature, the solvent is evaporated under reduced pressure (2.7 kPa) at 20° C., to give 2.4 g of 4-oxo-4-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]butyric acid in the form of a pale yellow paste which is used as it is.

Workup

  1. customthe solvent is evaporated under reduced pressure (2.7 kPa) at 20° C.

Sources & evidence

ORD record
ord-c21ee953c2f74566a3d519b46f4d8309
Source dataset
uspto-grants-2007_01
Patent number
US07166594B2

Reaction notes

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