Succinic anhydride → HCID 18521581, compound

Participants

Reaction Steps

0.72 g of succinic anhydride and then 1.5 cm3 of 95% 1-(pyrrolidinocarbonylmethyl)-piperazine are added to 20 cm3 of dioxane in a round-bottomed flask kept under a nitrogen atmosphere. After stirring for 4.75 hours at room temperature, the solvent is evaporated under reduced pressure (2.7 kPa) at 20° C., to give 2.4 g of 4-oxo-4-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]butyric acid in the form of a pale yellow paste which is used as it is.

Provenance & Evidence