HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → N-(Toluene-4sulfonyl)-N-methyl-L-phenylalanyl-D,L-phenylalanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Phenylalanine ethyl ester | HCID 76506 | — |
| Reactant | N-(toluene-4-sulfonyl)-N-methylphenylalanine | HCID 12069251 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-(Toluene-4sulfonyl)-N-methyl-L-phenylalanyl-D,L-phenylalanine | HCID 12069253 | — |
Reaction Steps
N-(Toluene-4-sulfonyl)-N-methylphenylalanine was coupled to L-phenylalanine ethyl ester using the procedure described in Method 3 (400 mg, 62%). The title compound was prepared via hydrolysis of the ethyl ester using NaOH in ethanol. Proton and carbon NMR analyis indicated a mixture of diastereomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07166580B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-6e8ea573a1834feb85f784c6351b8f89 |
| Source note | uspto-grants-2007_01 |