HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → Methyl 2-{methyl[(4-methylphenyl)sulfonyl]amino}acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Sarcosine methyl ester | HCID 83545 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | DMF N-(toluene-4-sulfonyl)sarcosine | HCID 86589137 | — |
| Reactant | HCID 178501396 | HCID 178501396 | — |
| Product | Methyl 2-{methyl[(4-methylphenyl)sulfonyl]amino}acetate | HCID 3277444 | — |
Reaction Steps
N-(Toluene-4-sulfonyl)sarcosine methyl ester was prepared from sarcosine methyl ester using the procedure described in Method 1. The title compound was prepared by coupling in DMF N-(toluene-4-sulfonyl)sarcosine with (N-benzyl)histidine methyl ester in the presence of BOP and NMM, to give after aqueous workup and flash chromatography, the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07166580B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-c662c3ca23cf4466b796cc1d425c1aba |
| Source note | uspto-grants-2007_01 |