HRID1374625

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=[CH][Sn]([CH2]CCC)([CH2]CCC)[CH2]CCC

HCID81998

Ethynyltributylstannane

C14H30Sn

结构：COC(=O)C(CC(C)(C)c1cc(F)ccc1Br)C(=O)c1ccccc1

HCID69516495

未命名化合物

PRODUCTS

生成物

结构：C=Cc1ccc(F)cc1C(C)(C)CC(C(=O)OC)C(=O)c1ccccc1

HCID69517640

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1

催化剂HCID178418397

未命名化合物

溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

A solution of 0.53 g (1.25 mmol) of 2-benzoyl-4-(2-bromo-5-fluorophenyl)-4-methylvaleric acid-methyl ester and 77 mg (0.07 mmol) of tetrakis(triphenylphosphine)palladium in 40 ml of toluene is refluxed with vinyl(tributyl)stannane for 8 hours. Then, it is concentrated by evaporation and purified by column chromatography on silica gel with hexane-ethyl acetate: 320 mg of product.

WORKUP

后处理

concentrationThen, it is concentrated by evaporation
custompurified by column chromatography on silica gel with hexane-ethyl acetate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-dbdb1ea4d7984ad8a0facd6ed5b26717
来源数据集: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07166592B2
来源说明: uspto-grants-2007_01

反应 SMILES

[CH3:1][O:2][C:3](=[O:25])[CH:4]([C:17](=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:5][C:6]([C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1Br)([CH3:8])[CH3:7].[CH:26]([Sn](CCCC)(CCCC)CCCC)=[CH2:27]>C1(C)C=CC=CC=1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH3:1][O:2][C:3](=[O:25])[CH:4]([C:17](=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:5][C:6]([C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[CH:26]=[CH2:27])([CH3:8])[CH3:7]