Acetic Acid → HCID 21908404, compound

HRID 1374631Notes

Reaction equation

HRID 1374631 reaction equation
C([O:3][C:4](=[CH:8][C:9]1([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])[CH2:11][CH2:10]1)[C:5]([OH:7])=[O:6])C.C(O)(=O)C.O>S(=O)(=O)(O)O>[Cl:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[C:9]1([CH2:8][C:4](=[O:3])[C:5]([OH:7])=[O:6])[CH2:11][CH2:10]1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 962WaterHCID 69516577HCID 69516577, compound

Product 1

HCID 21908404HCID 21908404, compoundYield 106.8%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

11.2 g of 2-ethoxy-3-[1-(2-chlorophenyl)-1-cyclopropyl]-acrylic acid is stirred in 230 ml of 1 M sulfuric acid and 42 ml of concentrated acetic acid for 24 hours at 110° C. Water is added, it is extracted with ethyl acetate, and ethyl acetate solution is washed with water. After drying (Na2SO4) and concentration by evaporation, 10.7 g of the product is obtained.

Workup

  1. extractionit is extracted with ethyl acetate, and ethyl acetate solution
  2. washis washed with water
  3. customAfter drying
  4. concentration(Na2SO4) and concentration
  5. customby evaporation

Sources & evidence

ORD record
ord-5c461acd69a940d3b19df576ccb6cfa6
Source dataset
uspto-grants-2007_01
Patent number
US07166592B2

Reaction notes

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