Tetrahydrofuran → HCID 21077393, compound

HRID 1374657Notes

Reaction equation

HRID 1374657 reaction equation
FC(F)(F)C([N:5]1[CH2:11][CH2:10][C:9]2[CH:12]=[CH:13][C:14]([NH:16][C:17]3[N:22]=[C:21]([NH:23][CH3:24])[C:20]([N+:25]([O-:27])=[O:26])=[CH:19][N:18]=3)=[CH:15][C:8]=2[CH2:7][CH2:6]1)=O.O1CCCC1.[OH-].[Na+]>O>[CH2:10]1[C:9]2[CH:12]=[CH:13][C:14]([NH:16][C:17]3[N:22]=[C:21]([NH:23][CH3:24])[C:20]([N+:25]([O-:27])=[O:26])=[CH:19][N:18]=3)=[CH:15][C:8]=2[CH2:7][CH2:6][NH:5][CH2:11]1

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 21077487HCID 21077487, compound

Product 1

HCID 21077393HCID 21077393, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

650 mg of 2-(3-trifluoroacetyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl-amino)-4-methylamino-5-nitro-pyrimidine, 20 ml tetrahydrofuran, 10 ml water and 3.2 ml of 1N sodium hydroxide solution are stirred for 2 hours at ambient temperature and then the reaction mixture is combined with 100 ml of water. The solid precipitated is suction filtered and dried.

Workup

  1. customThe solid precipitated
  2. filtrationfiltered
  3. customdried

Sources & evidence

ORD record
ord-17436641a3274bc487a04d31c9474506
Source dataset
uspto-grants-2007_01
Patent number
US07166599B2

Reaction notes

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