反应详情

温度

60 °C

8.81 g (0.045 mol) of dimethyl pyrimidine-4,6-dicarboxylate were dissolved in 200 ml of DMF, after which 6.25 g (0.045 mol) of 4-fluoro-3-methylbenzylamine were added and the mixture was stirred at 60° C. for 48 hours (h). The solvent was removed in vacuo and the residue was taken up in ethyl acetate. The organic phase was washed with a saturated solution of sodium hydrogen carbonate and 0.5 N HCl and then dried (MgSO4). After filtering, and evaporating the solvent in vacuo, the residue was stirred up in isopropanol. This resulted in 8.75 g of product, which was subjected to further reaction without any further purification.

1. customThe solvent was removed in vacuo
2. washThe organic phase was washed with a saturated solution of sodium hydrogen carbonate and 0.5 N HCl
3. dry with materialdried (MgSO4)
4. filtrationAfter filtering
5. customevaporating the solvent in vacuo
6. stirringthe residue was stirred up in isopropanol