HCID 22054593, compound → HCID 22054594, compound

HRID 1374759Notes

Reaction equation

HRID 1374759 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][O:13][C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][CH:15]=3)=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:22])[CH:3]=1>N1CCCCC1>[CH3:22][C:4]1[CH:3]=[C:2]([N:5]2[CH2:6][CH2:11][CH2:2][CH2:3][CH2:4]2)[C:11]2[C:6](=[CH:7][C:8]([CH2:12][O:13][C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][CH:15]=3)=[CH:9][CH:10]=2)[N:5]=1

Participants

3

Reactant 1

HCID 22054593HCID 22054593, compound

Product 1

HCID 22054594HCID 22054594, compoundYield 69.9%

Reagents, catalysts & solvents 1

HCID 8082PiperidineSolvent

Procedure

A solution of 4-(4-chloro-2-methyl-quinolin-7-ylmethoxy)-benzonitrile (example 54a, 100 mg, 0.32 mmol) in piperidine (1 mL) was heated at 100° C. for 21 h. After cooling the reaciton mixture was partitioned between sat. aq. sodium hydrogencarbonate solution and dichloromethane, the organic layer was separated, washed with brine, dried (MgSO4), and evaporated. Chromatography (SiO2, dichloromethane/methanol 19:1) yielded the title compound (40 mg, 32%). Light yellow gum, ISP-MS: m/e=358.4 ([M+H]+).

Workup

  1. temperatureAfter cooling the reaciton mixture
  2. customwas partitioned between sat. aq. sodium hydrogencarbonate solution and dichloromethane
  3. customthe organic layer was separated
  4. washwashed with brine
  5. dry with materialdried (MgSO4)
  6. customevaporated

Sources & evidence

ORD record
ord-7852f91c1b8c4edea73e3a18d726ac88
Source dataset
uspto-grants-2007_01
Patent number
US07166589B2

Reaction notes

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