Ethanol → HCID 11595925, compound

HRID 1374799Notes

Reaction equation

HRID 1374799 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[N+:18]([O-])=O)[NH:11][C:10]2([CH3:25])CC(O)=O)=[CH:4][CH:3]=1.ClC1C=CC(SC2C3C(=CC=[C:40]([C:43]([O:45][CH3:46])=[O:44])C=3)NC=2C)=CC=1.[CH2:48](O)C>[Pt]>[NH2:18][C:16]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:17]=1[C:9]([S:8][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)=[C:10]([CH3:25])[N:11]2[CH2:40][C:43]([O:45][CH2:46][CH3:48])=[O:44]

Participants

5

Reactant 3

HCID 702EthanolHCID 66966241HCID 66966241, compoundHCID 86599797HCID 86599797, compound

Product 1

HCID 11595925HCID 11595925, compound

Reagents, catalysts & solvents 1

HCID 23939PlatinumCatalyst

Procedure

A suspension of the product from example 55 part (ii) (2.25 g) in ethanol (170 ml) was stirred in the presence of 5% Pt/C (0.5 g) under 2 bar pressure of H2. After stirring overnight the catalyst was removed by filtration and the filtrates concentrated in vacuo. Purification by flash column chromatography (14% EtOAc/hexane as eluent) gave the sub-title compound (1.4 g).

Workup

  1. customwas removed by filtration
  2. concentrationthe filtrates concentrated in vacuo
  3. customPurification by flash column chromatography (14% EtOAc/hexane as eluent)

Sources & evidence

ORD record
ord-01198cf4a05b4a0d8c6c95b5ec7d1304
Source dataset
uspto-grants-2007_01
Patent number
US07166607B2

Reaction notes

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