1-Benzyl-4-(4-nitrobenzyl)piperazine → 4-[(4-Benzylpiperazin-1-yl)methyl]aniline

HRID 1374816Notes

Reaction equation

HRID 1374816 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pd]>[CH2:1]([N:8]1[CH2:9][CH2:10][N:11]([CH2:14][C:15]2[CH:16]=[CH:17][C:18]([NH2:21])=[CH:19][CH:20]=2)[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 7639351-Benzyl-4-(4-nitrobenzyl)piperazine

Product 1

HCID 180057134-[(4-Benzylpiperazin-1-yl)methyl]aniline

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Prepared analogously to Example Id by catalytic hydrogenation of 1.3 g (4.2 mmol) of 4-(4-benzylpiperazinomethyl)-nitrobenzene over palladium/charcoal.

Sources & evidence

ORD record
ord-0ddf7f1db5774eb294d3b5bfb4613652
Source dataset
uspto-grants-2007_01
Patent number
US07166615B2

Reaction notes

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