Water → HCID 178470689, compound

HRID 1374823Notes

Reaction equation

C(O[C:4](=[C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([NH:20][S:21]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)(=[O:23])=[O:22])[CH:18]=2)[NH:13][C:12]1=[O:30])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)C.[CH2:31]([O:33][C:34]([CH2:36][C:37]1[CH:43]=[CH:42][C:40]([NH2:41])=[CH:39][CH:38]=1)=[O:35])[CH3:32].O>CN(C=O)C>[CH2:31]([O:33][C:34]([CH2:36][C:37]1[CH:38]=[CH:39][C:40]([NH:41]/[C:4](=[C:11]2\[C:12](=[O:30])[NH:13][C:14]3[C:19]\2=[CH:18][C:17]([NH:20][S:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)(=[O:22])=[O:23])=[CH:16][CH:15]=3)/[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=2)=[CH:42][CH:43]=1)=[O:35])[CH3:32]

Participants

Conditions

Temperature: 140 °C

Procedure

0.84 g (2 mmol) of 3-(1-ethoxy-1-phenyl-methylidene)-5-phenylsulphonylamino-2-indolinone and 0.39 g (2.2 mmol) of 4-ethoxycarbonylmethyl-aniline are dissolved in 10 ml of DMF. The mixture is heated to 140° C. for 5 hours. Then water is added while the mixture is cooled with ice and stirred for 1 hour at ambient temperature. The precipitate formed is suction filtered, washed with water, a little isopropanol and ether, then dried in vacuo.

Workup

temperatureis cooled with ice
customThe precipitate formed
filtrationfiltered
washwashed with water
dry with materiala little isopropanol and ether, then dried in vacuo

Sources & evidence

ORD record: ord-f9877c3ef2db442384a67a17ad5f53ef
Source dataset: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07166615B2

Reaction notes

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