4-(Aminomethyl)piperidine → tert-Butyl 4-(aminomethyl)piperidine-1-carboxylate--hydrogen chloride (1/1)

Participants

Reaction Steps

By using 4-aminomethylpiperidine 5.71 g as a starting material, tert-butyl 4-aminomethylpiperidine-1-carboxylate was prepared according to the method described in Synthetic Commun., 22(16), 2357–2360 (1992). The resulting compound was dissolved in 80 ml of ethyl acetate, and the solution was added with 4N hydrogen chloride-ethyl acetate and stirred. The precipitated solids were collected by filtration to obtain the title compound (10.27 g, yield: 82%).

Provenance & Evidence