4-(Aminomethyl)piperidine → tert-Butyl 4-(aminomethyl)piperidine-1-carboxylate--hydrogen chloride (1/1)

HRID 1374828Notes

Reaction equation

HRID 1374828 reaction equation
NCC1CCNCC1.[NH2:9][CH2:10][CH:11]1[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]1.C(OCC)(=O)C.[ClH:30]>C(OCC)(=O)C>[ClH:30].[NH2:9][CH2:10][CH:11]1[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]1

Participants

5

Reactant 3

HCID 235274-(Aminomethyl)piperidineHCID 7368171-Boc-4-(aminomethyl)piperidineHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 2756034tert-Butyl 4-(aminomethyl)piperidine-1-carboxylate--hydrogen chloride (1/1)Yield 82%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

By using 4-aminomethylpiperidine 5.71 g as a starting material, tert-butyl 4-aminomethylpiperidine-1-carboxylate was prepared according to the method described in Synthetic Commun., 22(16), 2357–2360 (1992). The resulting compound was dissolved in 80 ml of ethyl acetate, and the solution was added with 4N hydrogen chloride-ethyl acetate and stirred. The precipitated solids were collected by filtration to obtain the title compound (10.27 g, yield: 82%).

Workup

  1. customwas prepared
  2. filtrationThe precipitated solids were collected by filtration

Sources & evidence

ORD record
ord-2ddb96259e7d41479389f7fbc4da843d
Source dataset
uspto-grants-2007_01
Patent number
US07166617B2

Reaction notes

Loading…