反应详情

Methyl 4-bromo-2-methylbenzoate (19.0 mmol) was dissolved in dimethylformamide (2.7 mL) and methanol (1.1 mL), and the solution was heated at 80° C. and then added with CuBr (1.09 mmol). After stirring was continued for 2 hours under heating, the mixture was cooled to room temperature. The mixture was added with diethyl ether (25 mL) and filtered. The filtrate was washed four times with water, an aqueous sodium bicarbonate solution, and then with saturated brine, and dried over sodium sulfated. The drying agent was removed by filtration and the filtrate was concentrated to give the title compound.

1. temperatureunder heating
2. filtrationfiltered
3. washThe filtrate was washed four times with water
4. dry with materialan aqueous sodium bicarbonate solution, and then with saturated brine, and dried over sodium
5. customThe drying agent was removed by filtration
6. concentrationthe filtrate was concentrated