1-Phenylimidazolidin-2-one → HCID 17839083, compound

HRID 1374852Notes

Reaction equation

HRID 1374852 reaction equation
[C:1]1([N:7]2[CH2:11][CH2:10][NH:9][C:8]2=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:14][CH2:15][O:16][Si:17]([C:20]([CH3:23])([CH3:22])[CH3:21])([CH3:19])[CH3:18]>>[Si:17]([O:16][CH2:15][CH2:14][N:9]1[CH2:10][CH2:11][N:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8]1=[O:12])([C:20]([CH3:23])([CH3:22])[CH3:21])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 2552731-Phenylimidazolidin-2-oneHCID 3608067(2-Bromoethoxy)-tert-butyldimethylsilane

Product 1

HCID 17839083HCID 17839083, compound

Procedure

By using 1-phenylimidazolidin-2-one obtained by the method described in literature (J. Org. Chem., 1951, 16, 1829) and t-butyldimethylsilyl 2-bromoethyl ether obtained by the method of Example 92a, 1-[2-(t-butyldimethylsilyloxy)ethyl]-3-phenylimidazolidin-2-one was obtained as crude product by similar procedures to those of Example 151a. By using the resulting product, the title compound was obtained as colorless solid by similar procedures to those of Example 92b (yield: 75%).

Workup

  1. customobtained by the method
  2. customobtained by the method of Example 92a

Sources & evidence

ORD record
ord-084a8b07edec4ea5b2383dd7e30c7713
Source dataset
uspto-grants-2007_01
Patent number
US07166617B2

Reaction notes

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