Acetone → 1937215-88-7

Participants

Reaction Conditions

Reaction Steps

2-[[1-[2-(4-Fluorophenyl)-2-oxoethyl]piperidin-4-yl]methyl]isoindolin-1-one hydrochloride (the compound of Example 1, 39.4 mmol) was added to water (30 mL) and acetone (210 mL), and mixture was heated at 60° C. for dissolution. The mixture was added dropwise with ethyl acetate (100 mL) and stand for cooling to room temperature. The crystals precipitated were collected by filtration and the resulting crystals were washed with ethyl acetate and dried under reduced pressure to obtain the title compound (yield: 79%).

Provenance & Evidence